Drug Database
BF

BF-611 (Turkadon / heparin, LMW, Fidia)

✓ Approved

Fidia · SERPINC1

What is BF-611?

BF-611 is a therapeutic agent developed by Fidia. It is approved for therapeutic indications via injectable (others).

Drug Profile

Brand NamesTurkadon, heparin, LMW, Fidia
CompanyFidia
Molecular TargetSERPINC1, F2, F10
RouteInjectable (Others)
StatusApproved
Sources: ClinicalTrials.gov, Fidia

Mechanism of Action

Molecular Targets

BF-611 acts on 3 molecular targets:

SERPINC1serpin family C member 1 (ATIII, AT3D)
F2coagulation factor II, thrombin (THPH1, PT)
F10coagulation factor X (FXA, FX)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

BF-611 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Vascular disordersThrombosis✓ Approved

Related Research Articles

PubMedBJPsych open2026-09-18

Revised long version (KEZ-R) and short form (KEZ-S) of the Cologne Questionnaire on Attitudes towards Coercive Measures in in-patient mental healthcare.

Schmitz-Buhl Mario M, Baar Immanuel I, Gouzoulis-Mayfrank Euphrosyne E

Attitudes of mental health professionals towards coercive measures are crucial with respect to both the application of these methods and efforts to reduce coercion in psychiatric care. Existing instruments primarily assess cognitive aspects, often neglecting emotional and contextual dimensions. The Cologne Questionnaire on Attitudes towards Coercive Measures (KEZ) addresses these gaps but has so far only been available in German and in a relatively long format. To revise the KEZ for international use and develop and validate a short version suitable for both research and clinical practice. The revised version was intended to ensure a balanced representation of different coercive measures. A revised long version (KEZ-R) was developed and administered via an anonymous online survey to 611 mental health professionals from Germany and German-speaking Switzerland. Psychometric properties of the German version were analysed using factor and reliability analyses. A short form (KEZ-S) was derived on the basis of theoretical and content-related criteria. The 40-item KEZ-R replicated the original three-factor structure of the KEZ and showed good reliability (Cronbach's α = 0.87). The 15-item KEZ-S demonstrated strong correlation with the long version and acceptable overall reliability (α = 0.67). Both versions captured cognitive, emotional and interactional aspects of attitudes towards coercive measures. The KEZ-R and KEZ-S are reliable instruments for assessment of attitudes towards coercive measures in psychiatric settings. Although validation was conducted in German, the availability of an English translation supports international use and future validation studies.

PMID 42757609
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PubMedRespirology case reports2026-09-17

Rescue Diagnosis of Upper-Lobar Station 12U Lymph Nodes Using the Thin Convex-Probe EBUS Bronchoscope (BF-UCP190F): A Report of Two Cases.

Kitano Toki T, Takigawa Yuki Y, Sato Ken K, Goda Mayu M et al.

BF-UCP190F (Olympus) is a newly developed thin convex-probe endobronchial ultrasound (TCP-EBUS) bronchoscope, improving access to distal bronchi. We report two cases in which TCP-EBUS enabled successful endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) of the upper-lobar station 12U lymph node (#12U LN) via B3 after conventional bronchoscopic forceps sampling failed to provide a definitive diagnosis. In the first case, forceps biopsy of a left upper lobe tumour was non-diagnostic; TCP-EBUS-guided EBUS-TBNA of the left #12U LN established lung adenocarcinoma with N1 involvement. In the second case, the initial bronchoscopy yielded only cytological evidence of carcinoma without histological confirmation; TCP-EBUS-guided sampling of the right #12U LN revealed metastatic small cell carcinoma. In both cases, the pathological diagnosis of EBUS-TBNA guided subsequent treatment. These cases suggest that BF-UCP190F expands the diagnostic range of bronchoscopy and may serve as a valuable rescue technique for sampling upper lobar hilar lymph nodes in clinical practice.

PMID 42751719
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PubMedThe American journal of clinical nutrition2026-09-17

Bidirectional longitudinal associations between adiposity and emotional and uncontrolled eating in an observational UK population-based cohort.

Ruggiero Cara F CF, Kudlek Laura L, Kininmonth Alice R AR, Mueller Julia J et al.

Eating behaviour traits (EBTs), including uncontrolled eating (UE) and emotional eating (EE), are associated with higher body weight and adiposity. However, evidence on temporal and bidirectional relationships between EBTs and adiposity in adults is limited. This study aimed to examine longitudinal, bidirectional associations between EBTs and adiposity in a large population-based cohort of middle-aged adults. Data were from Phase 1 (2005-2015) and 2 (2014-2020) from the Fenland cohort, a prospective study of adults living in Cambridgeshire, UK, born between 1950 and 1975. UE and EE were analysed in relation to objectively measured BMI and dual-energy X-ray absorptiometry-derived %BF . Bidirectional associations between baseline EBTs and changes in adiposity, and between baseline adiposity and changes in EBTs, were examined using bivariate latent change score models. Analyses were stratified by sex and adjusted for age, education, and household income. In both females and males, higher BMI at phase 1 was associated with greater increases in UE (e.g. females: γ1 = 0.13; 95% CI = 0.006, 0.25; p = 0.04) and EE (e.g. females: γ1 = 0.54; 95% CI = 0.34, 0.74; p <0.0001) from phase 1 to phase 2, while baseline UE and EE were not associated with subsequent changes in BMI. Similar patterns were observed for %BF, with higher baseline adiposity associated with increases in UE and EE over time, but not vice versa. Sensitivity analyses generally supported the primary findings, although associations between adiposity and subsequent uncontrolled eating in females were attenuated and no longer statistically significant. Findings challenge assumptions that UE and EE are drivers of adult weight gain and instead suggest that higher adiposity may contribute to the development or escalation of dysregulated eating behaviours. Interventions may benefit from addressing the behavioural and psychological consequences of higher body weight alongside traditional weight-focused strategies.

PMID 42754170
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PubMedAnnals of neurology2026-09-16

Alzheimer's Co-Pathology Burden on Basal Forebrain Atrophy and Cognitive Impairment in Dementia with Lewy Bodies: A Cross-Sectional Pilot Study.

Urso Daniele D, Giannelli Thomas T, Tafuri Benedetta B, Giannoni-Luza Stefano S et al.

Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative dementia after Alzheimer's disease (AD), with significant pathological overlap between the two conditions. However, the impact of Alzheimer's co-pathology on basal forebrain (BF) atrophy and its relationship with neurodegeneration and cognitive decline in patients with DLB remains underexplored. Forty patients with DLB and 14 healthy controls (HCs) were included from the Centre for Neurodegenerative Diseases, University of Bari. Participants underwent neuropsychological evaluations, 3T magnetic resonance imaging (MRI) scans, and Alzheimer's biomarkers assessment. Patients with DLB were grouped by AD co-pathology using in vivo biomarkers. BF and hippocampal volumes and mean cortical thickness values were analyzed using analysis of covariance (ANCOVA), adjusted for age, sex, and total intracranial volume. Mediation analyses were conducted to examine the indirect effects of Alzheimer's pathology and BF atrophy on neurodegeneration (hippocampal volume and cortical thickness) and cognitive function (Mini-Mental State Examination [MMSE]). Patients with DLB exhibited significant BF atrophy compared with HCs (p < 0.001). AD co-pathology was associated with greater BF atrophy (p = 0.046) and reduced mean cortical thickness (p = 0.025). Significant correlations were found between BF volume and the pTAU181/Aβ1-42 ratio (p = 0.009) and between BF volume and MMSE scores (p = 0.016). Mediation analysis revealed that BF atrophy mediated the relationship between the pTau/Aβ42 ratio and neurodegeneration, and that the BF has a direct association with cognitive impairment. AD co-pathology in DLB exacerbates BF atrophy, correlating with cognitive decline. These results emphasize the need to consider AD co-pathology in evaluating neurodegeneration in DLB, suggesting future studies should explore targeted interventions to address this pathological overlap. ANN NEUROL 2026.

PMID 42747246
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PubMedJournal of medical Internet research2026-09-16

Feasibility and Acceptability of Perioperative Application of Biofeedback-Based Virtual Reality vs Control for Pain and Anxiety in Children and Adolescents Undergoing Surgery: Pilot Randomized Controlled Trial.

Lin Anna M AM, Rachwal Brenna B, Asti Lindsey L, Orgil Zandantsetseg Z et al.

The impact of biofeedback-based virtual reality (VR-BF) on pain and anxiety in pediatric surgical patients remains unexplored. The objective of this study was to evaluate the feasibility and acceptability of perioperative VR-BF use in children and adolescents. We performed a single-blind, 2-arm, randomized pilot trial. Children aged 12 to 18 years undergoing surgery with expected moderate-to-severe postoperative pain and more than 1 overnight admission were randomized (1:1) to the intervention or control group. Participants in the intervention group received VR-BF using ForeVR (functional outcome response to engaging virtual reality [VR]), a novel, gamified digital intervention that integrates respiratory biofeedback into an immersive VR environment to train children in vagal tone modulation, and the control group used Manage My Pain, an app designed to assist patients with recognizing and reflecting on their pain. Participants and caregivers were unblinded to their assigned intervention but blinded to the other arm's technology; data analysts were masked to treatment allocation. The primary outcome was feasibility, assessed through recruitment, enrollment and randomization, retention, adherence, and outcome data collection. Secondary outcomes evaluated acceptability, including satisfaction and tolerability. Exploratory outcomes, including pain intensity, pain unpleasantness, and anxiety, were assessed in the VR-BF group. This trial was registered at ClinicalTrials.gov (NCT04943874) and is complete. Of the 202 patients who were eligible for study participation, 70 were enrolled, and 65 (92.9%) patients completed the study (VR-BF, n=30; control, n=35). Female participants accounted for 41 (58.6%) of the participants, and the median age of participants was 16.2 (IQR 14.1-17.5) years. VR-BF participants completed a median of 4 (IQR 3-5) preoperative training sessions and 7 (IQR 2-9) postoperative sessions. Acceptability was high; only 2 (6.7%) would not use VR-BF again. Six VR-BF patients reported mild, transient adverse events (AEs), none of which were serious. VR-BF patients with baseline pain and anxiety scores ≥2 reported a median 1-point (IQR 0-2) reduction in pain intensity, unpleasantness, and anxiety immediately and up to 30 minutes postsession. Perioperative use of VR-BF is feasible and acceptable in pediatric surgical patients, with high recruitment, retention, and satisfaction and no serious AEs. These findings support a subsequent trial to assess the efficacy and long-term impact of this novel technology.

PMID 42748484
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PubMedFrontiers in microbiology2026-09-16

Association of feeding methods in early life with gut microbiota in neonates.

Lai Huimin H, Pan Xiongfeng X, Xiang Shiting S, Peng Yunlong Y et al.

The research on the gut microbiota of neonates and preterm neonates by conventional feeding methods is still limited. This study aimed to systematically characterize gut microbiota variations across three feeding methods in neonates, with a specific focus on preterm neonates. This study included 265 neonates from the Hunan Children's Hospital cohort, categorized by feeding methods into breast-fed (BF, n = 122), formula-fed (FF, n = 86), and mixed-fed (MF, n = 57) groups. Additionally, the analysis was further stratified into preterm and full-term neonates to investigate the relationship between feeding methods and gut microbiota. Gut microbiota composition was assessed using 16S rRNA gene sequencing of neonatal fecal samples. Microbial patterns associated with feeding methods were identified through MaAsLin2 analyses. Unadjusted analyses showed that compared with the FF and MF groups, the BF group exhibited significantly higher relative abundances of Bifidobacterium (p = 0.018) and Staphylococcus (p = 0.039). In addition, the relative abundance of Akkermansia (p = 0.046) in the FF group was higher than that in the other two groups. MaAsLin2 analyses revealed the FF group had higher relative abundances of Verrucomicrobiota (Coef = 1.46, p = 0.001, FDR q-value = 0.055) and Akkermansia (Coef = 1.53, p = 0.001, FDR q-value = 0.040) than those in the BF group among all neonates, particularly preterm neonates. The BF neonates displayed enriched Staphylococcus (Coef = -1.47, p = 0.009, FDR q-value = 0.154) and depleted Rothia (Coef = 1.45, p = 0.004, FDR q-value = 0.121). The MF group showed higher Streptococcus abundance relative to the BF group (Coef = 0.95, p = 0.019, FDR q-value = 0.204). Functional prediction indicated potential group differences in propionate metabolism and degradation of valine, leucine, and isoleucine pathways, particularly in preterm neonates. Our study demonstrates an association between feeding methods and gut microbiota composition in neonates. The BF neonates exhibited increased relative abundance of Staphylococcus and decreased relative abundances of Akkermansia and Rothia compared with FF neonates. The MF group had higher relative abundance of Streptococcus than BF group. Furthermore, among preterm neonates, FF group was associated with a higher abundance of Akkermansia compared with BF group.

PMID 42746414
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