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CTC-111 (Anact C)

✓ Approved

Meiji Holdings · PROC

What is CTC-111?

CTC-111 is a therapeutic agent developed by Meiji Holdings. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesAnact C
CompanyMeiji Holdings
Molecular TargetPROC
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, Meiji Holdings

Mechanism of Action

Molecular Targets

CTC-111 acts on 1 molecular target:

PROCprotein C, inactivator of coagulation factors Va and VIIIa (APC, PROC1)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

CTC-111 is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Vascular disordersThrombosis✓ Approved
Skin and subcutaneous tissue disordersPurpura fulminans✓ Approved

Related Research Articles

PubMedAnalytical chemistry2026-11-11

High-Purity Magnetic Fluidic Isolation of Viable Circulating Tumor Cells Enables Single-Cell Multi-Omics Profiling.

Xia Chenfeng C, Wang Xiaobo X, Li Xuejie X, Wu Shuting S et al.

Circulating tumor cells (CTCs) provide a minimally invasive window into tumor evolution, yet their rarity, phenotypic heterogeneity, and vulnerability to processing-induced damage impose stringent requirements on upstream enrichment workflows for single-cell molecular analysis. Here, we report a magnetic-fluidic analytical platform for rapid, high-purity isolation of viable CTCs from whole blood and downstream single-cell profiling. The device integrates immunomagnetic labeling with hydrodynamically confined laminar flow, enabling magnetically tagged tumor cells to be laterally deflected into a CTC-enriched outlet, while unlabeled hematologic cells are depleted through waste outlets. After optimization of inlet flow rates, the platform achieved an MCF-7 sorting efficiency of 97.98 ± 0.60% and a white blood cell removal efficiency of 99.96 ± 0.01%. In spiked whole-blood samples, the enriched fraction showed a CTC purity of 99.68 ± 0.08%, while post-sorting viability remained comparable to untreated controls, supporting compatibility with downstream single-cell assays. Application to breast cancer patient blood samples enabled the detection of 3-6 CTCs from 2 mL of blood. Coupling this enrichment workflow with single-cell RNA sequencing generated 56 high-quality single-cell transcriptomes from a HER2-low breast cancer patient and identified epithelial CTC-like and immune cell populations, with negligible ERBB2 transcript levels observed in the epithelial CTC-like population. Exploratory single-cell proteomic analysis further demonstrated measurable intercellular heterogeneity among patient-derived CTCs. This magnetic-fluidic workflow provides a practical analytical route for viability-preserving CTC enrichment and single-cell molecular characterization in liquid biopsy.

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PubMedPhysical chemistry chemical physics : PCCP2026-11-11

Coverages and configurations of CO* and H* on Pt(111) under realistic reaction conditions.

Hossain Sifat S, Punyapu Venkata Rohit VR, Christopher Phillip P, Getman Rachel B RB

Lateral interactions between co-adsorbed species can produce non-random spatial organization that governs the availability of reactive motifs relevant to catalytic behavior. For CO* and H* co-adsorbed on Pt(111), these interactions determine how the two species distribute across the surface and therefore which local CO*-H* configurations are available under reaction conditions. In this work, we combine density functional theory, cluster expansions, and grand canonical Monte Carlo simulations to determine how CO* and H* organize on Pt(111), and subsequently use electronic surface charge as a controlled perturbation to examine how this organization responds to changes in the underlying energetics. On neutral Pt(111), CO*-H* first-nearest-neighbor interactions are strongly repulsive (0.42 eV), CO*-CO* first-nearest-neighbor interactions are moderately repulsive (0.12 eV), and H*-H* interactions are comparatively weak. These interactions cause CO* to nucleate into islands that grow and coalesce with increasing CO* coverage, while H* preferentially occupies regions outside CO*-rich domains. Consequently, the abundance of CO*-H* nearest-neighbor configurations varies non-monotonically with CO* coverage, reaching a maximum at intermediate coverage before decreasing as CO* islands grow and the adsorbates become increasingly segregated. Positive surface charge strengthens CO* adsorption but also increases CO*-CO* repulsion, producing higher CO* coverages, a broader distribution of CO* island sizes, and larger low-coverage regions between islands where H* can adsorb away from CO*. This suppresses CO*-H* nearest-neighbor configurations relative to the neutral surface. Negative charging weakens CO* adsorption, producing lower CO* coverages, higher H* coverages, and less consolidated CO* islands, thereby increasing the prevalence of mixed CO*-H* local environments. At intermediate CO* coverage, CO* islands enter a regime of accelerated growth and coalescence that coincides with a shallow plateau in H* coverage. This coincidence suggests that the onset of CO* island coalescence is accompanied by a reorganization of the co-adsorbed layer. Further, it illustrates the strong influence of lateral interactions on the formation of potentially reactive motifs, highlighting how they become influential in determining catalytic reactivity.

PMID 43012335
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PubMedSmall methods2026-11-11

Crystallographic Design of Electrodeposited Copper for Ultra-Low-Temperature Cu-Cu Direct Bonding.

Han Haneul H, Yoon Sanghwa S, Kim Youjung Y, Levane Amber Sunny AS et al.

Low-temperature Cu-Cu direct bonding (<150°C) for 3D integration faces a severe bottleneck from interfacial voids caused by limited atomic diffusion. While nanocrystalline Cu (NC-Cu) has emerged as a promising bonding material owing to its high stored energy, the thermodynamic influence of initial crystallographic orientation remains unclear. Here, we systematically investigate the orientation-dependent bonding thermodynamics of NC-Cu thin films with (100), (111), and (101) orientations. Despite high internal energy, (100) and (111) Cu consume significant energy for internal defect curing (dislocation glide and twin annihilation), inducing void aggregation. Conversely, (101) Cu, despite not possessing the largest absolute total driving force, directs the largest fraction of its available positive driving force toward macroscopic grain-boundary migration, thereby achieving extensive interfacial-crossing growth and enhanced overall mechanical reliability. We demonstrate that reliable bonding requires targeted allocation of grain boundary energy, establishing a novel crystallographic design principle for advanced heterogeneous integration and solid-state joining technologies.

PMID 43010168
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PubMedNano letters2026-11-11

Atomic Lift-Off of Wafer-Scale Single-Crystalline Gold Membranes Enables Buried-Interface Epitaxy for Flexible Oxide Electronics.

Sun Yongbin Y, Chi Hanwen H, Shen Ziyue Z, Wang Kaixin K et al.

Flexible oxide electronics require inorganic semiconductors that maintain high-performance under bending, yet scalable approaches to wafer-scale single-crystalline (SC) oxide films and, critically, atomically sharp metal/oxide contacts remain limited. Here, we introduce a buried-interface epitaxy strategy based on atomic lift-off of epitaxial metal films to create atomically defined SC metal/oxide heterostructures in flexible architectures. We fabricate 2-in. freestanding SC Au(111) membranes and employ film-flipping to expose the originally buried Au/Si epitaxial interface as an intrinsically atomically flat growth surface. This converts conventional surface deposition into interface deposition, enabling wafer-scale epitaxial Cu2O(111)/Au with a flat interface. The interface-deposited flexible Cu2O exhibits nearly 2-fold higher carrier mobility and photocurrent, while maintaining stable transport under bending. Flexible Cu2O photocathodes further exhibit 1.6 times higher full-angle light harvesting and 5.6 times higher photocurrent-to-mass metrics compared with rigid counterparts. This work establishes freestanding SC metals as transferable epitaxial templates for flexible oxide electronics and energy devices.

PMID 43012602
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PubMedBMC research notes2026-11-11

Serum brain-derived neurotrophic factor is associated with diabetic complications and glycemic control in type 2 diabetes: an exploratory analysis of the ADNI cohort.

Liu Minne M, Guan Jian J, Shi Jie J, Xu Xiaohan X et al.

To investigate the association between serum brain-derived neurotrophic factor (BDNF) levels and the clinical profile as well as complications in patients with type 2 diabetes mellitus (T2DM). A total of 185 participants were enrolled, including 35 healthy controls, 111 T2DM patients without complications, and 39 T2DM patients with complications. Serum BDNF levels declined progressively across groups (18.1→13.5→10.2 ng/mL, P < 0.001). BDNF was moderately negatively correlated with HbA1c (ρ=-0.41, P < 0.001) and weakly positively correlated with MoCA scores (ρ = 0.18, P = 0.013). Multivariable regression confirmed that diabetic complications (β=-2.05, P = 0.021) and higher HbA1c (β=-1.03, P < 0.001) were independently associated with lower BDNF. Participants in the lowest BDNF quartile had elevated odds of complications (OR = 16.67, 95% CI 1.56-178.57, P = 0.013). BDNF showed limited discriminative ability for cognitive impairment (AUC = 0.603). Exploratory mediation analysis suggested a potential pathway of BDNF→HbA1c→cognitive function. Serum BDNF is associated with glycemic control and complication burden in T2DM.

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PubMedArrhythmia & electrophysiology review2026-11-11

Ventricular Pulsed Field Ablation: State-of-the-art Review of Preclinical and Clinical Evidence.

Martinez-Gomez Eduardo E, Asirvatham Samuel J SJ, Siontis Konstantinos C KC

Pulsed field ablation (PFA) is a paradigm shift in the field of cardiac electrophysiology. The well-demonstrated success with atrial PFA is generating enthusiasm for ventricular applications of PFA, for which the clinical experience is still in its infancy, however. This study is a systematic review and critical appraisal of the published preclinical and clinical evidence on ventricular PFA, involving a total of 111 primary articles (55 preclinical and 56 clinical). An increasing number of PFA platforms and catheters are being used in the ventricle in clinical practice. This appraisal evaluates the impact of ablation parameters in association with lesion depth and volume, and synthesises the available studies of safety and efficacy outcomes for ablation of ventricular tachycardia and premature ventricular complexes with PFA, as reported in case reports and case series from around the world. The cumulative published evidence amounts to a total of 434 patients ablated with PFA for ventricular arrhythmias, with generally favourable acute and long-term results, while the understanding of safety constraints continues to be explored.

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