Drug Database
SY

synth conjugated estrogens (Enjuvia)

✓ Approved

Teva Pharmaceutical Industries Ltd. · ESR1

What is synth conjugated estrogens?

synth conjugated estrogens is a therapeutic agent developed by Teva Pharmaceutical Industries Ltd.. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesEnjuvia
CompanyTeva Pharmaceutical Industries Ltd.
Molecular TargetESR1
RouteOral (PO)
StatusApproved

Mechanism of Action

Molecular Targets

synth conjugated estrogens acts on 1 molecular target:

ESR1estrogen receptor 1 (ER, ESR)
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Therapeutic Indications

synth conjugated estrogens is developed for 3 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Reproductive system and breast disordersAtrophic vulvovaginitis✓ Approved
Surgical and medical proceduresHormone replacement therapy✓ Approved
Reproductive system and breast disordersMenopausal symptoms✓ Approved

Related Research Articles

PubMedSmart molecules : open access2026-07-25

Unraveling the effect of topological structures of B/N-doped conjugated macrocycles on spectral properties: A computational study.

Guo Wen-Yu WY, Zeng Yi Y, Xu Yu-Meng YM, Chen Pang-Kuan PK et al.

Organic conjugated macrocycles have attracted significant attention for their applications in smart luminescent materials, yet precise modulation of their spectral properties remains challenging. In this work, a series of fully B-doped, fully N-doped and hybrid B/N-doped conjugated macrocycles were designed to systematically investigate the relationship between their topological structures and spectral properties. Three topological factors of heteroatom doped macrocycles were incorporated into the molecular design: ring size, number of triarylborane (Ar3B) and triarylamine (Ar3N) segments, and π-linker between segments. For macrocycles with phenyl as the π-linker, at a fixed ring size, both absorption (λ abs) and emission (λ emi) wavelength exhibit a first increase followed by a decrease as the number of Ar3N segments increases accompanied by the decrease of Ar3B segments. For each size of macrocycles, the reddest λ emi usually contains a balanced ratio of Ar3B and Ar3N segments, with at least two Ar3B and Ar3N segments. Regardless of the ring size of macrocycles, the ratio of Ar3B to Ar3N segments plays a crucial role in tuning the spectral properties. A more balanced ratio enhances both electron-donating and electron-accepting abilities, thereby strengthening the intramolecular charge transfer effect and leading to a more redshifted emission spectra. A similar trend of λ emi that first red-shift then blue-shift was also observed for macrocycles with fluorene or biphenyl as π-linkers. Notably, at a given ring size and relative number of Ar3N and Ar3B, phenyl-linked macrocycles exhibit a more pronounced red-shift than those with fluorene or biphenyl linkers, and fluorene-linked systems show slightly red-shifted spectra relative to biphenyl-linked analogs. These spectral trends are well explained by the electronic properties of the fundamental building blocks. This work provides important theoretical guidance for the development of smart luminescent materials based on conjugated macrocycles.

PubMedChemical science2026-07-25

Dihydrobenzofuro[3,2-b]benzofuran: a light-driven molecular switch with fluorescence switching, bistability, and intrinsic chirality.

Hassan Fathy F, Velmurugan Nivedha N, Tan Jingyun J, Yi Yuan-Qiu-Qiang YQ et al.

Designing photochromic materials with thermally stable bistability, fluorescence switching, and structural responsiveness remains a key challenge in responsive materials. In this study, we introduce photochromic behavior in 4b,9b-dihydrobenzofuro[3,2-b]benzofuran derivatives (DHBs). Guided by bond dissociation energies, we demonstrate that DHB derivatives undergo a reversible, light-induced regioselective ring-opening reaction accompanied by significant changes in structural, electronic, and photophysical properties. Upon UV illumination at 285 nm, the non-conjugated, weakly emissive closed-ring DHB undergoes a regioselective ring-opening to yield a conjugated, hydroxy-functionalized isomer that exhibits strong fluorescence. The reverse ring-closure occurs under 325 nm light, with no observable thermal back reaction, establishing a thermally stable, bistable molecular switch. The rigid, fused structure of DHB possesses intrinsic chirality, as confirmed by single-crystal X-ray diffraction revealing racemic twin crystals with nearly equal enantiopure domains. Enantiomeric separation by chiral HPLC enables the study of its stereochemical and chiroptical properties. Spectroscopic analyses, in both solution and thin films, together with DFT calculations, elucidate photoinduced fluorescence switching behavior, distinct HOMO-LUMO energy levels, and structural transformations between the two isomers. Notably, asymmetric substitution directs the site of bond cleavage, providing a handle to control photochemical reaction pathways. These results highlight the potential of DHB derivatives as a multifunctional photochromic scaffold and open new opportunities for the design of responsive materials with tunable optical and electronic properties.

PubMedACS physical chemistry Au2026-07-25

Decoding Chemical Resonance in π‑Conjugated Systems.

Szczepanik Dariusz W DW, Wieczorkiewicz Pawel A PA

Understanding the electronic structure of (anti)-aromatic poly- and macrocyclic π-conjugated systems remains a central challenge in contemporary chemistry, given their importance in materials science, molecular electronics, photophysics, and catalysis. While magnetically induced ring currents and NMR-based descriptors have long served as key indicators of (anti)-aromatic character, the extent to which such magnetic observables reflect the full ground-state π-bonding architecture becomes less transparent in large and topologically complex systems. Here we introduce a wavefunction-based analytical protocol the π-Bond Delocalization Function (BDFπ) which maps the spatial organization of localized and delocalized π-bonding directly from the ground-state one-electron density matrix. Rather than relying on predefined resonance models or orbital localization schemes, the method extracts bonding topology from the complete occupied π-space. This enables a direct comparison between the global π-electron distribution and the more selective subset of frontier-orbital excitations that dominate magnetic response phenomena. Applied to representative poly- and macrocyclic systems frequently discussed in the context of global (anti)-aromaticity, BDFπ reveals that magnetic ring currents and bonding delocalization need not coincide quantitatively in extended conjugated frameworks. Magnetic descriptors predominantly probe perturbative response channels, whereas the underlying resonance structure reflects the collective organization of the entire occupied π-manifold. By explicitly relating these two perspectives, the present framework provides a coherent and chemically transparent account of how resonance topology and experimentally observable magnetic behavior are connected and where they may diverge in large conjugated architectures.

PubMedFrontiers in oncology2026-07-25

Concurrent B-cell acute lymphoblastic leukemia and plasma cell neoplasm with plasmablastic features supporting divergent evolution from a shared precursor: a case report.

Babić Antonija A, Franić Šimić Ivana I, Knežević Josip J, Gjadrov Kuveždić Koraljka K et al.

B-cell malignancies comprise a biologically diverse group of neoplasms, with only rare reports describing the co-occurrence of two distinct lymphoid entities. While concurrent presentation of mature B-cell neoplasms has been documented, the simultaneous occurrence of B-cell acute lymphoblastic leukemia (B-ALL) and plasma cell neoplasm (PCN) has previously been reported rarely. Such cases may provide insight into the clonal architecture and evolutionary pathways underlying lymphoid malignancies. We report a 76-year-old man presenting with cytopenias and leukocytosis, in whom initial bone marrow evaluation and immunophenotyping established a diagnosis of B-ALL with a pre-B phenotype. At the time of diagnosis, flow cytometry also identified a distinct population of aberrant plasma cells, raising the possibility of a concurrent plasma cell neoplasm. Follow-up bone marrow analysis confirmed the coexistence of two immunophenotypically and morphologically distinct malignant populations: immature lymphoblasts consistent with B-ALL and clonal plasma cells. Initial ALL-directed therapy induced remission of both components. However, subsequent disease evolution demonstrated a clear phenotypic shift, with relapse characterized by expansion of a plasmablastic/plasma cell population consistent with PCN, while the B-ALL component remained undetectable by minimal residual disease assessment. Treatment was therefore redirected toward a myeloma-based regimen, which was limited by toxicity and failed to achieve disease control. Genomic analysis supported the presence of two clonally related but distinct malignancies. These findings support a model of early clonal divergence from a common progenitor rather than independent malignancies or linear differentiation. This case highlights the complexity of clonal evolution in B-cell malignancies and underscores the importance of integrated genomic and immunophenotypic analysis in understanding disease biology.

PubMedJournal of the American Pharmacists Association : JAPhA2026-07-25

Community pharmacists' perceptions of long-acting injectable buprenorphine administration in community pharmacies: A cross-sectional survey study.

Marley Grace G, Farrel Brianna B, Carpenter Delesha D

Long-acting injectable buprenorphine (LAI-B) is an evidence-based medication for opioid use disorder (MOUD), but its implementation in community pharmacies has not been well studied. This study's objective was to assess southeastern North Carolina (NC) community pharmacist perspectives on the perceived acceptability, appropriateness, and feasibility of LAI-B administration and identify the barriers and facilitators to LAI-B administration in community pharmacies. We conducted an online survey of practicing community pharmacists between January 14 and March 14, 2026. The survey assessed knowledge of and willingness to administer LAI-B, perceived benefits and barriers, training needs, and perceived acceptability, appropriateness, and feasibility of administering LAI-B. Descriptive statistics are reported. Forty-four eligible responses were included in the analysis (response rate= 16%). On average, pharmacists were neutral to somewhat willing to administer LAI-B and also had neutral-to-positive perceptions of acceptability, appropriateness, and feasibility. The most frequently endorsed benefits of LAI-B were decreased diversion, supporting patients in recovery, reducing overdose deaths, and increasing revenue. The most prominent barriers involved reimbursement and payment. Other barriers included limited training, workflow constraints, and lack of provider referrals. Pharmacists reported low knowledge regarding LAI-B Risk Evaluation and Mitigation Strategy requirements, follow-up monitoring, and storage, and expressed interest in training on those topics. Pharmacy-based LAI-B administration could be a promising strategy to expand access to MOUD. However, implementation will require clearer reimbursement pathways, targeted training, and workflow support.

PubMedJournal of environmental sciences (China)2026-07-25

Bloom of Blixaea quinquecornis (Abé) Gottschling (Dinophyceae) with Chaetoceros tenuissimus Meunier in the South Atlantic: Morphology, molecular characterization, and toxins.

Guennes Marcella M, Goulart Amanda Santos AS, Salgueiro Fabiano F, Lange Priscila Kienteca PK et al.

Blixaea quinquecornis (Abé) Gottschling is a monotypic and cosmopolitan marine dinoflagellate with a Chaetoceros derived tertiary plastid (a dinotom). An extensive bloom of B. quinquecornis that covered 80 km² and extended to 15 km away from the coastline occurred at the Brazilian Northeast coast. B. quinquecornis abundances of 2.3 × 10⁶ cells/L were recorded, causing water discoloration. Molecular analysis of field cells confirmed the identity of B. quinquecornis and the diatom Chaetoceros tenuissimus Meunier, that was found in close association with the dinoflagellate. B. quinquecornis presented the typical morphology of the species, with a conical epitheca, and hypotheca with four antapical spines. Mean cell length was 23.3 ± 2.8 µm and width 19.5 ± 2.8 µm. Toxin screening (PSTs, palytoxins, brevetoxins) showed negative results, though the presence of a putative new palytoxin analogue cannot be excluded. This study presented the first comprehensive characterization of B. quinquecornis, combining morphological description, molecular phylogeny and toxin screening, and contributed with the second molecular sequence of this species. It is noteworthy that B. quinquecornis was found in close association with Chaetoceros tenuissimus, the original diatom-derived tertiary plastid in B. quinquecornis. Future research should prioritize establishing cultures of B. quinquecornis to definitively resolve the nature of its plastid association (kleptoplastidy vs. permanent endosymbiosis) and to enable more comprehensive toxin biosynthesis investigations.

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